Ultra-Long-Acting Basal Insulin Analogues

Ultra-Long-Acting Basal Insulin Analogues

Seyed Adel Jahed, MD

Islamic Azad University, Tehran Medical Branch

14 ^rd  June 2012

RIES, Tehran, Iran

AGENDA

• Why Search For Ultra-long-actings?
• The Pipeline Of The Ultra-long-actings
• Overview Of Insulin Degludec, its PK and PD
• Clinical evidences in Degludec usage

• Despite 90 years of insulin use and advances in therapy for patients with diabetes, treatment remains associated with notable limitations.
• Attempts to achieve near normoglycemia with subcutaneous insulin continue to raise important questions, including:
  • The choice of preparation
  • Injection regimen
  • How to reduce incidence of hypoglycemia
  • How to prevent excess weight gain
  • How to avoid other effects of inappropriate hyperinsulinemia

Using Insulin: Importance of Ease of Use

• Patients with DM spend >2 hr/day on self care, which includes glucose monitoring, sorting medications, deciding about insulin dosing, and dietary decisions.
• A recent trend in many disorders, including DM₂, has been the introduction of long-acting drugs that could be administered less than daily to improve adherence while minimizing side effects.